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MEDICINE • Good News Network
A vaccine made from your own tumor fights melanomaA personalized cancer vaccine paired with standard immunotherapy cut the risk of melanoma recurrence and death by 49 percent five years after surgery, according to results presented June 1 at the American Society of Clinical Oncology meeting in Chicago. New York University researchers at the Perlmutter Cancer Center tested the vaccine, intismeran, alongside the drug pembrolizumab in 107 patients whose tumors had been removed. Among those who got the combination, 68.8 percent stayed cancer free, compared with 49.1 percent on pembrolizumab alone. Overall survival reached 92.2 percent in the combination group. The vaccine is built from each patient's own tumor, using mRNA to teach the immune system to spot 34 abnormal proteins unique to their cancer. "Our study offers strong evidence to melanoma patients," said senior investigator Janice Mehnert, a professor at NYU Grossman School of Medicine. A larger phase 3 trial is already running. Side effects were manageable, mostly fatigue and chills.
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KINDNESS • InspireMore
A toy garbage truck made this little boy's whole weekA garbage truck crew in the United States left a small boy his own toy version of their truck after he missed their weekly visit, and his mother has not stopped talking about it since. Shepherd, son of Sarah Bowden, runs out to greet Mr. Q and Mr. Zakee of Republic Services whenever they pass the house. They high five him, swap jokes, and generally treat a child waving at a sanitation truck like the regular he is. Recently Shep was at school when the crew came by, which he took hard. So Mr. Q and Mr. Zakee came back with a gift, a tiny Republic Services truck of his own. Bowden filmed his face lighting up and posted it online. "Watching my son learn kindness, friendship, and community from people in our everyday life has been really special," she wrote. The toy truck does not collect actual garbage. Shep does not seem to mind.
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MOTIVATIONAL • InspireMore
At 17, he broke the curse no man in his family beatTyon Newsome walked across the stage at William M. Raines High School in Jacksonville, Florida, and became the first male on either side of his family to earn a high school diploma. His uncle, Antonio Brown, watched from the stands and cried. He posted the video, mostly to his family, and strangers found it anyway. Tyon almost did not make it. "I almost quit a couple times. I thought I couldn't do it, I thought it was too hard for me," he told WLTV. He did not quit. Antonio called the graduation a moment that reached back through generations. "Seeing him get to finish it and complete it the right way, that really meant a lot to me," he said. The comments filled with people claiming someone nearby was cutting onions. One wrote: "He has broken the curse this is AWESOME." Tyon is 17.
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DELIGHT • InspireMore
Strangers gave a hardworking veteran the chance to finally restA TikTok video that ran just eight seconds long has raised more than $135,000 for a military veteran who works at John Wayne Airport in Orange County, California. James Blair has trouble walking, but he shows up to the job anyway. A traveler named LaCinda noticed him moving slowly through his shift and filmed it, not to mock him but to find help. "Watching him work so hard, he could barely move, barely walk truly broke my heart," she wrote. "I know there has to be a way we can help him retire." The clip has 5.8 million views, which is the rare case of an algorithm doing something genuinely useful. LaCinda then started a GoFundMe with a modest goal of giving Blair a chance to rest. "I don't know his full story yet. I don't know why he's still working," she wrote. The video found Blair too. The two have since connected.
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DELIGHT • Good News Network
His double-tap on the wrong button won nearly $900,000Allan Taylor pressed the wrong button buying a lottery ticket online, and the mistake earned him nearly $900,000. The 65-year-old from Derbyshire, England, accidentally subscribed to two tickets for the Postcode Lottery instead of one. When his postcode, S42 6AE in Tupton, came up in last Saturday's Millionaire Street draw, he collected two checks worth £333,333 each. "I must have ticked it twice when I was subscribing," Taylor said. "This was the best mistake I've ever made." His wife, Bev, recalled noticing the duplicate ticket and asking him why he had two. He said he didn't know. The windfall is the year's biggest single-player prize for the lottery, and it lands just weeks after the couple retired early in March. Bev, a former dementia mental health nurse, said she still can't believe it. Taylor, a car fan, has always wanted an Aston Martin. At his age, he figures he could get in, but might not get out.
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Did today's letter lift you? Pass it to someone who'd want the same.
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With love, The Editor
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